Victor Frankenstein chose to isolate himself from the rest of society due to his dedication of wanting to use his talents in creating a creature which he believed would make history. He occupied most of his time by constantly working and studying what he loved most: science. "From this day natural philosophy, and particularly chemistry, in the most comprehensive term, became my sole occupation." His drive to make a mark in society caused him to devote most of his time studying that socializing with other people was never really an option. Even his father disapproved his thirst for new knowledge. Victor quotes his father who says, "Ah! Cornelius Agrippa! My dear Victor, do not waste your time upon this; it is sad trash." The fact that his mother died when he was young and his father believes Victor's personal interest is trash shows that he never really had anyone who he can share his interests to. As a response to this, Victor decided to isolate himself and put his extensive knowledge of science to use on his own.
Like Frankenstein, the monster he created also suffers from loneliness. The fact that he is 8 ft. tall and extremely hideous causes him to be isolated from the rest of society. Since he is the only one of his kind, he has a hard time trying to interact with other people since people would instantly run away in terror and/or physically abuse him. "...I hardly placed my foot within the door before the children shrieked, and one of the women fainted. The whole village was roused; some fled, some attacked me, until, grievously bruised by stones..." The monster, unlike Victor who brought isolation upon himself, is forced into isolation because of his physical appearance. His appearance makes it impossible to communicate with other people since they don't even give him a chance to speak.